In 2009, British newspaper The Guardian spoke of conductor Isaac Karabtchevsky as "one of the living icons" of Brazil. The expression has its reason for being: since the 70's, Karabtchevsky has developed one of the most brilliant careers in the Brazilian music scene, working for 26 years as the conductor of the Brazilian Symphony Orchestra and leading a bolder project on popular communications throughout Latin America, called "Aquarius", which brought together thousands of people and enabled, thereby, the emergence an audience sensitive to classical music in the region.

This period of intense activity coincides with his stay in Europe, serving as artistic director of various orchestras and theaters, such as the Tonkünstlerorchester in Vienna (1988-1994), the Teatro La Fenice in Venice (1995-2001), and, finally, as the director of the Orchestre National des Pays de la Loire (2004-2010). Among the theaters and prestigious orchestras of this phase are also the Salle Pleyel in Paris, the Konzertgebouw in Amsterdam, the Musikverein in Vienna, the Royal Festival Hall in London, the Accademia di Santa Cecilia in Rome, the Teatro Real in Madrid, the Staatsoper in Vienna, Carnegie Hall in New York, the Teatro Comunale of Bologna, The Rai in Torino, the Teatro Colón in Buenos Aires, the Deutsche Oper am Rhein in Düsseldorf, the Cologne Gurzenich Orchestra, the Tokyo Philharmonic Orchestra etc.

As of 2004, Karabtchevsky took over Petrobras Symphony Orchestra, a group characterized by a unique system of self-management. A new stage in his career began, with predominance of his vast experience in the symphonic repertoire, and, also, the point of view of someone who was used to titles as important as Schoenberg's Erwartung; The Flying Dutchman, Tannhäuser, and Tristan and Isolde by Wagner; Britten's Billy Budd; and other numerous productions that led him to direct, at the Washington Opera, a remarkable achievement of Boris Godunov, considered by critic Tim Page, from the Washington Post, as the best of the 1999-2000 season. From this period come the commendations he received from the Austrian government for the cultural services rendered to the country, and, also, the medal "Chevalier des Arts et des Lettres", from the French government. In addition to that, he was also recognized by virtually all the Brazilian states.

In early 2011, Karabtchevsky was invited to direct the Symphonic of Heliópolis (Heliópolis is the most disadvantaged community in the city of São Paulo). In parallel, he assumed the artistic direction of the Baccarelli Institute. Between 2011 and 2016, he recorded Villa-Lobos full symphonies – responding to an invitation by the São Paulo Symphony Orchestra. The project is the result of a thorough effort of rebuilding scores and rescuing an important, though often overlooked aspect, of the composer's production. He also served as musical director of the Municipal Theatre of São Paulo and the Porto Alegre Symphony Orchestra.

Since 2000, he directs, in Italy, masterclasses for conductors from all over the world, in the Musica Riva Festival. In the Olinda's International Music Workshop, in Brazil, he teaches the same courses with great success. Currently, he is also responsible for the artistic program of the Municipal Theater of Rio de Janeiro.

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